Effect of Losmapimod on Cardiovascular Outcomes in Patients Hospitalized With Acute Myocardial Infarction: A Randomized Clinical Trial.
Identifieur interne : 002040 ( Main/Exploration ); précédent : 002039; suivant : 002041Effect of Losmapimod on Cardiovascular Outcomes in Patients Hospitalized With Acute Myocardial Infarction: A Randomized Clinical Trial.
Auteurs : Michelle L. O'Donoghue [États-Unis] ; Ruchira Glaser [États-Unis] ; Matthew A. Cavender [États-Unis] ; Philip E. Aylward [Australie] ; Marc P. Bonaca [États-Unis] ; Andrzej Budaj [Pologne] ; Richard Y. Davies [États-Unis] ; Mikael Dellborg [Suède] ; Keith A A. Fox [Royaume-Uni] ; Jorge Antonio T. Gutierrez [États-Unis] ; Christian Hamm [Allemagne] ; Robert G. Kiss [Hongrie] ; František Kovar ; Julia F. Kuder [États-Unis] ; Kyung Ah Im [États-Unis] ; John J. Lepore [États-Unis] ; Jose L. Lopez-Sendon [Espagne] ; Ton Oude Ophuis [Pays-Bas] ; Alexandr Parkhomenko [Ukraine] ; Jennifer B. Shannon [États-Unis] ; Jindrich Spinar [République tchèque] ; Jean-Francois Tanguay [Canada] ; Mikhail Ruda [Russie] ; P Gabriel Steg [France] ; Pierre Theroux [Canada] ; Stephen D. Wiviott [États-Unis] ; Ian Laws [États-Unis] ; Marc S. Sabatine [États-Unis] ; David A. Morrow [États-Unis]Source :
- JAMA [ 1538-3598 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Algorithmes, Calendrier d'administration des médicaments, Cyclopropanes (effets indésirables), Cyclopropanes (usage thérapeutique), Femelle, Hospitalisation, Humains, Infarctus du myocarde (enzymologie), Infarctus du myocarde (mortalité), Infarctus du myocarde (traitement médicamenteux), Inhibiteurs de protéines kinases (effets indésirables), Inhibiteurs de protéines kinases (usage thérapeutique), Ischémie myocardique (), Mâle, Méthode en double aveugle, Protéine C-réactive (analyse), Prévention secondaire, Pyridines (effets indésirables), Pyridines (usage thérapeutique), Revascularisation myocardique, Récidive, Sujet âgé, p38 Mitogen-Activated Protein Kinases (antagonistes et inhibiteurs), Échec thérapeutique.
- MESH :
- analyse : Protéine C-réactive.
- antagonistes et inhibiteurs : p38 Mitogen-Activated Protein Kinases.
- effets indésirables : Cyclopropanes, Inhibiteurs de protéines kinases, Pyridines.
- enzymologie : Infarctus du myocarde.
- mortalité : Infarctus du myocarde.
- traitement médicamenteux : Infarctus du myocarde.
- usage thérapeutique : Cyclopropanes, Inhibiteurs de protéines kinases, Pyridines.
- Adulte d'âge moyen, Algorithmes, Calendrier d'administration des médicaments, Femelle, Hospitalisation, Humains, Ischémie myocardique, Mâle, Méthode en double aveugle, Prévention secondaire, Revascularisation myocardique, Récidive, Sujet âgé, Échec thérapeutique.
English descriptors
- KwdEn :
- Aged, Algorithms, C-Reactive Protein (analysis), Cyclopropanes (adverse effects), Cyclopropanes (therapeutic use), Double-Blind Method, Drug Administration Schedule, Female, Hospitalization, Humans, Male, Middle Aged, Myocardial Infarction (drug therapy), Myocardial Infarction (enzymology), Myocardial Infarction (mortality), Myocardial Ischemia (prevention & control), Myocardial Ischemia (surgery), Myocardial Revascularization, Protein Kinase Inhibitors (adverse effects), Protein Kinase Inhibitors (therapeutic use), Pyridines (adverse effects), Pyridines (therapeutic use), Recurrence, Secondary Prevention, Treatment Failure, p38 Mitogen-Activated Protein Kinases (antagonists & inhibitors).
- MESH :
- chemical , adverse effects : Cyclopropanes, Protein Kinase Inhibitors, Pyridines.
- chemical , analysis : C-Reactive Protein.
- chemical , antagonists & inhibitors : p38 Mitogen-Activated Protein Kinases.
- chemical , therapeutic use : Cyclopropanes, Protein Kinase Inhibitors, Pyridines.
- drug therapy : Myocardial Infarction.
- enzymology : Myocardial Infarction.
- mortality : Myocardial Infarction.
- prevention & control : Myocardial Ischemia.
- surgery : Myocardial Ischemia.
- Aged, Algorithms, Double-Blind Method, Drug Administration Schedule, Female, Hospitalization, Humans, Male, Middle Aged, Myocardial Revascularization, Recurrence, Secondary Prevention, Treatment Failure.
Abstract
p38 Mitogen-activated protein kinase (MAPK)-stimulated inflammation is implicated in atherogenesis, plaque destabilization, and maladaptive processes in myocardial infarction (MI). Pilot data in a phase 2 trial in non-ST elevation MI indicated that the p38 MAPK inhibitor losmapimod attenuates inflammation and may improve outcomes.
DOI: 10.1001/jama.2016.3609
PubMed: 27043082
Affiliations:
- Allemagne, Australie, Canada, Espagne, France, Hongrie, Pays-Bas, Pologne, Royaume-Uni, Russie, République tchèque, Suède, Ukraine, États-Unis
- Caroline du Nord, Communauté de Madrid, District fédéral central, Gueldre, Hongrie centrale, Massachusetts, Moravie, Pennsylvanie, Écosse, Île-de-France
- Brno, Budapest, Madrid, Moscou, Nimègue, Paris
Links toward previous steps (curation, corpus...)
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Le document en format XML
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Sabatine</name><affiliation wicri:level="2"><nlm:affiliation>TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Morrow, David A" sort="Morrow, David A" uniqKey="Morrow D" first="David A" last="Morrow">David A. Morrow</name><affiliation wicri:level="2"><nlm:affiliation>TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27043082</idno><idno type="pmid">27043082</idno><idno type="doi">10.1001/jama.2016.3609</idno><idno type="wicri:Area/PubMed/Corpus">001F87</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001F87</idno><idno type="wicri:Area/PubMed/Curation">001F62</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001F62</idno><idno type="wicri:Area/PubMed/Checkpoint">001F62</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001F62</idno><idno type="wicri:Area/Ncbi/Merge">003358</idno><idno type="wicri:Area/Ncbi/Curation">003358</idno><idno type="wicri:Area/Ncbi/Checkpoint">003358</idno><idno type="wicri:Area/Main/Merge">002039</idno><idno type="wicri:Area/Main/Curation">002040</idno><idno type="wicri:Area/Main/Exploration">002040</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effect of Losmapimod on Cardiovascular Outcomes in Patients Hospitalized With Acute Myocardial Infarction: A Randomized Clinical Trial.</title><author><name sortKey="O Donoghue, Michelle L" sort="O Donoghue, Michelle L" uniqKey="O Donoghue M" first="Michelle L" last="O'Donoghue">Michelle L. O'Donoghue</name><affiliation wicri:level="2"><nlm:affiliation>TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Glaser, Ruchira" sort="Glaser, Ruchira" uniqKey="Glaser R" first="Ruchira" last="Glaser">Ruchira Glaser</name><affiliation wicri:level="2"><nlm:affiliation>Metabolic Pathways and Cardiovascular Unit, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Metabolic Pathways and Cardiovascular Unit, Research and Development, GlaxoSmithKline, Collegeville</wicri:cityArea></affiliation></author><author><name sortKey="Cavender, Matthew A" sort="Cavender, Matthew A" uniqKey="Cavender M" first="Matthew A" last="Cavender">Matthew A. Cavender</name><affiliation wicri:level="2"><nlm:affiliation>TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Aylward, Philip E" sort="Aylward, Philip E" uniqKey="Aylward P" first="Philip E" last="Aylward">Philip E. Aylward</name><affiliation wicri:level="1"><nlm:affiliation>South Australian Health and Medical Research Institute, Flinders University Medical Centre, Adelaide, South Australia, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>South Australian Health and Medical Research Institute, Flinders University Medical Centre, Adelaide, South Australia</wicri:regionArea><wicri:noRegion>South Australia</wicri:noRegion></affiliation></author><author><name sortKey="Bonaca, Marc P" sort="Bonaca, Marc P" uniqKey="Bonaca M" first="Marc P" last="Bonaca">Marc P. Bonaca</name><affiliation wicri:level="2"><nlm:affiliation>TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Budaj, Andrzej" sort="Budaj, Andrzej" uniqKey="Budaj A" first="Andrzej" last="Budaj">Andrzej Budaj</name><affiliation wicri:level="1"><nlm:affiliation>Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Postgraduate Medical School, Grochowski Hospital, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Davies, Richard Y" sort="Davies, Richard Y" uniqKey="Davies R" first="Richard Y" last="Davies">Richard Y. Davies</name><affiliation wicri:level="2"><nlm:affiliation>Metabolic Pathways and Cardiovascular Unit, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Metabolic Pathways and Cardiovascular Unit, Research and Development, GlaxoSmithKline, Collegeville</wicri:cityArea></affiliation></author><author><name sortKey="Dellborg, Mikael" sort="Dellborg, Mikael" uniqKey="Dellborg M" first="Mikael" last="Dellborg">Mikael Dellborg</name><affiliation wicri:level="1"><nlm:affiliation>Sahlgrenska University Hospital/Ostra and Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Sahlgrenska University Hospital/Ostra and Sahlgrenska Academy, University of Gothenburg, Gothenburg</wicri:regionArea><wicri:noRegion>Gothenburg</wicri:noRegion></affiliation></author><author><name sortKey="Fox, Keith A A" sort="Fox, Keith A A" uniqKey="Fox K" first="Keith A A" last="Fox">Keith A A. Fox</name><affiliation wicri:level="2"><nlm:affiliation>Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, Scotland.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Écosse</region></placeName><wicri:cityArea>Centre for Cardiovascular Science, University of Edinburgh, Edinburgh</wicri:cityArea></affiliation></author><author><name sortKey="Gutierrez, Jorge Antonio T" sort="Gutierrez, Jorge Antonio T" uniqKey="Gutierrez J" first="Jorge Antonio T" last="Gutierrez">Jorge Antonio T. Gutierrez</name><affiliation wicri:level="2"><nlm:affiliation>TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Hamm, Christian" sort="Hamm, Christian" uniqKey="Hamm C" first="Christian" last="Hamm">Christian Hamm</name><affiliation wicri:level="1"><nlm:affiliation>Kerckhoff Heart Center, Bad Nauheim, University of Giessen, Giessen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Kerckhoff Heart Center, Bad Nauheim, University of Giessen, Giessen</wicri:regionArea><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Kiss, Robert G" sort="Kiss, Robert G" uniqKey="Kiss R" first="Robert G" last="Kiss">Robert G. Kiss</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, Military Hospital, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Cardiology, Military Hospital, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Kovar, Frantisek" sort="Kovar, Frantisek" uniqKey="Kovar F" first="František" last="Kovar">František Kovar</name><affiliation><nlm:affiliation>Department of Internal Medicine I, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic.</nlm:affiliation><wicri:noCountry code="subField">Slovak Republic</wicri:noCountry></affiliation></author><author><name sortKey="Kuder, Julia F" sort="Kuder, Julia F" uniqKey="Kuder J" first="Julia F" last="Kuder">Julia F. Kuder</name><affiliation wicri:level="2"><nlm:affiliation>TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Im, Kyung Ah" sort="Im, Kyung Ah" uniqKey="Im K" first="Kyung Ah" last="Im">Kyung Ah Im</name><affiliation wicri:level="2"><nlm:affiliation>TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Lepore, John J" sort="Lepore, John J" uniqKey="Lepore J" first="John J" last="Lepore">John J. Lepore</name><affiliation wicri:level="2"><nlm:affiliation>Metabolic Pathways and Cardiovascular Unit, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Metabolic Pathways and Cardiovascular Unit, Research and Development, GlaxoSmithKline, Collegeville</wicri:cityArea></affiliation></author><author><name sortKey="Lopez Sendon, Jose L" sort="Lopez Sendon, Jose L" uniqKey="Lopez Sendon J" first="Jose L" last="Lopez-Sendon">Jose L. Lopez-Sendon</name><affiliation wicri:level="3"><nlm:affiliation>Cardiovascular Division, University Hospital La Paz, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Cardiovascular Division, University Hospital La Paz, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Ophuis, Ton Oude" sort="Ophuis, Ton Oude" uniqKey="Ophuis T" first="Ton Oude" last="Ophuis">Ton Oude Ophuis</name><affiliation wicri:level="3"><nlm:affiliation>Canisius-Wilhelmina Hospital, Nijmegen, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Canisius-Wilhelmina Hospital, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Parkhomenko, Alexandr" sort="Parkhomenko, Alexandr" uniqKey="Parkhomenko A" first="Alexandr" last="Parkhomenko">Alexandr Parkhomenko</name><affiliation wicri:level="1"><nlm:affiliation>Ukranian Strazhesko Institute of Cardiology, Kiev, Ukraine.</nlm:affiliation><country xml:lang="fr">Ukraine</country><wicri:regionArea>Ukranian Strazhesko Institute of Cardiology, Kiev</wicri:regionArea><wicri:noRegion>Kiev</wicri:noRegion></affiliation></author><author><name sortKey="Shannon, Jennifer B" sort="Shannon, Jennifer B" uniqKey="Shannon J" first="Jennifer B" last="Shannon">Jennifer B. Shannon</name><affiliation wicri:level="2"><nlm:affiliation>PAREXEL International, Durham, North Carolina.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>PAREXEL International, Durham</wicri:cityArea></affiliation></author><author><name sortKey="Spinar, Jindrich" sort="Spinar, Jindrich" uniqKey="Spinar J" first="Jindrich" last="Spinar">Jindrich Spinar</name><affiliation wicri:level="3"><nlm:affiliation>University Hospital, Jihlavska, Brno, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>University Hospital, Jihlavska, Brno</wicri:regionArea><placeName><settlement type="city">Brno</settlement><region>Moravie</region></placeName></affiliation></author><author><name sortKey="Tanguay, Jean Francois" sort="Tanguay, Jean Francois" uniqKey="Tanguay J" first="Jean-Francois" last="Tanguay">Jean-Francois Tanguay</name><affiliation wicri:level="1"><nlm:affiliation>Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Heart Institute and University of Montreal, Montreal, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Ruda, Mikhail" sort="Ruda, Mikhail" uniqKey="Ruda M" first="Mikhail" last="Ruda">Mikhail Ruda</name><affiliation wicri:level="3"><nlm:affiliation>Cardiology Research Center, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Cardiology Research Center, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Steg, P Gabriel" sort="Steg, P Gabriel" uniqKey="Steg P" first="P Gabriel" last="Steg">P Gabriel Steg</name><affiliation wicri:level="3"><nlm:affiliation>Département Hospitalo-Universitaire FIRE, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, and Université Paris-Diderot, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département Hospitalo-Universitaire FIRE, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, and Université Paris-Diderot, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Theroux, Pierre" sort="Theroux, Pierre" uniqKey="Theroux P" first="Pierre" last="Theroux">Pierre Theroux</name><affiliation wicri:level="1"><nlm:affiliation>Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Heart Institute and University of Montreal, Montreal, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Wiviott, Stephen D" sort="Wiviott, Stephen D" uniqKey="Wiviott S" first="Stephen D" last="Wiviott">Stephen D. Wiviott</name><affiliation wicri:level="2"><nlm:affiliation>TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Laws, Ian" sort="Laws, Ian" uniqKey="Laws I" first="Ian" last="Laws">Ian Laws</name><affiliation wicri:level="2"><nlm:affiliation>Metabolic Pathways and Cardiovascular Unit, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Metabolic Pathways and Cardiovascular Unit, Research and Development, GlaxoSmithKline, Collegeville</wicri:cityArea></affiliation></author><author><name sortKey="Sabatine, Marc S" sort="Sabatine, Marc S" uniqKey="Sabatine M" first="Marc S" last="Sabatine">Marc S. Sabatine</name><affiliation wicri:level="2"><nlm:affiliation>TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Morrow, David A" sort="Morrow, David A" uniqKey="Morrow D" first="David A" last="Morrow">David A. Morrow</name><affiliation wicri:level="2"><nlm:affiliation>TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author></analytic><series><title level="j">JAMA</title><idno type="eISSN">1538-3598</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Algorithms</term><term>C-Reactive Protein (analysis)</term><term>Cyclopropanes (adverse effects)</term><term>Cyclopropanes (therapeutic use)</term><term>Double-Blind Method</term><term>Drug Administration Schedule</term><term>Female</term><term>Hospitalization</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Myocardial Infarction (drug therapy)</term><term>Myocardial Infarction (enzymology)</term><term>Myocardial Infarction (mortality)</term><term>Myocardial Ischemia (prevention & control)</term><term>Myocardial Ischemia (surgery)</term><term>Myocardial Revascularization</term><term>Protein Kinase Inhibitors (adverse effects)</term><term>Protein Kinase Inhibitors (therapeutic use)</term><term>Pyridines (adverse effects)</term><term>Pyridines (therapeutic use)</term><term>Recurrence</term><term>Secondary Prevention</term><term>Treatment Failure</term><term>p38 Mitogen-Activated Protein Kinases (antagonists & inhibitors)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Algorithmes</term><term>Calendrier d'administration des médicaments</term><term>Cyclopropanes (effets indésirables)</term><term>Cyclopropanes (usage thérapeutique)</term><term>Femelle</term><term>Hospitalisation</term><term>Humains</term><term>Infarctus du myocarde (enzymologie)</term><term>Infarctus du myocarde (mortalité)</term><term>Infarctus du myocarde (traitement médicamenteux)</term><term>Inhibiteurs de protéines kinases (effets indésirables)</term><term>Inhibiteurs de protéines kinases (usage thérapeutique)</term><term>Ischémie myocardique ()</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Protéine C-réactive (analyse)</term><term>Prévention secondaire</term><term>Pyridines (effets indésirables)</term><term>Pyridines (usage thérapeutique)</term><term>Revascularisation myocardique</term><term>Récidive</term><term>Sujet âgé</term><term>p38 Mitogen-Activated Protein Kinases (antagonistes et inhibiteurs)</term><term>Échec thérapeutique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Cyclopropanes</term><term>Protein Kinase Inhibitors</term><term>Pyridines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>C-Reactive Protein</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>p38 Mitogen-Activated Protein Kinases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Cyclopropanes</term><term>Protein Kinase Inhibitors</term><term>Pyridines</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Protéine C-réactive</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>p38 Mitogen-Activated Protein Kinases</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Myocardial Infarction</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Cyclopropanes</term><term>Inhibiteurs de protéines kinases</term><term>Pyridines</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Infarctus du myocarde</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Myocardial Infarction</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Myocardial Infarction</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infarctus du myocarde</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Myocardial Ischemia</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Myocardial Ischemia</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infarctus du myocarde</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Cyclopropanes</term><term>Inhibiteurs de protéines kinases</term><term>Pyridines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Algorithms</term><term>Double-Blind Method</term><term>Drug Administration Schedule</term><term>Female</term><term>Hospitalization</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Myocardial Revascularization</term><term>Recurrence</term><term>Secondary Prevention</term><term>Treatment Failure</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Algorithmes</term><term>Calendrier d'administration des médicaments</term><term>Femelle</term><term>Hospitalisation</term><term>Humains</term><term>Ischémie myocardique</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Prévention secondaire</term><term>Revascularisation myocardique</term><term>Récidive</term><term>Sujet âgé</term><term>Échec thérapeutique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">p38 Mitogen-activated protein kinase (MAPK)-stimulated inflammation is implicated in atherogenesis, plaque destabilization, and maladaptive processes in myocardial infarction (MI). Pilot data in a phase 2 trial in non-ST elevation MI indicated that the p38 MAPK inhibitor losmapimod attenuates inflammation and may improve outcomes.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Espagne</li><li>France</li><li>Hongrie</li><li>Pays-Bas</li><li>Pologne</li><li>Royaume-Uni</li><li>Russie</li><li>République tchèque</li><li>Suède</li><li>Ukraine</li><li>États-Unis</li></country><region><li>Caroline du Nord</li><li>Communauté de Madrid</li><li>District fédéral central</li><li>Gueldre</li><li>Hongrie centrale</li><li>Massachusetts</li><li>Moravie</li><li>Pennsylvanie</li><li>Écosse</li><li>Île-de-France</li></region><settlement><li>Brno</li><li>Budapest</li><li>Madrid</li><li>Moscou</li><li>Nimègue</li><li>Paris</li></settlement></list><tree><noCountry><name sortKey="Kovar, Frantisek" sort="Kovar, Frantisek" uniqKey="Kovar F" first="František" last="Kovar">František Kovar</name></noCountry><country name="États-Unis"><region name="Massachusetts"><name sortKey="O Donoghue, Michelle L" sort="O Donoghue, Michelle L" uniqKey="O Donoghue M" first="Michelle L" last="O'Donoghue">Michelle L. O'Donoghue</name></region><name sortKey="Bonaca, Marc P" sort="Bonaca, Marc P" uniqKey="Bonaca M" first="Marc P" last="Bonaca">Marc P. Bonaca</name><name sortKey="Cavender, Matthew A" sort="Cavender, Matthew A" uniqKey="Cavender M" first="Matthew A" last="Cavender">Matthew A. Cavender</name><name sortKey="Davies, Richard Y" sort="Davies, Richard Y" uniqKey="Davies R" first="Richard Y" last="Davies">Richard Y. Davies</name><name sortKey="Glaser, Ruchira" sort="Glaser, Ruchira" uniqKey="Glaser R" first="Ruchira" last="Glaser">Ruchira Glaser</name><name sortKey="Gutierrez, Jorge Antonio T" sort="Gutierrez, Jorge Antonio T" uniqKey="Gutierrez J" first="Jorge Antonio T" last="Gutierrez">Jorge Antonio T. Gutierrez</name><name sortKey="Im, Kyung Ah" sort="Im, Kyung Ah" uniqKey="Im K" first="Kyung Ah" last="Im">Kyung Ah Im</name><name sortKey="Kuder, Julia F" sort="Kuder, Julia F" uniqKey="Kuder J" first="Julia F" last="Kuder">Julia F. Kuder</name><name sortKey="Laws, Ian" sort="Laws, Ian" uniqKey="Laws I" first="Ian" last="Laws">Ian Laws</name><name sortKey="Lepore, John J" sort="Lepore, John J" uniqKey="Lepore J" first="John J" last="Lepore">John J. Lepore</name><name sortKey="Morrow, David A" sort="Morrow, David A" uniqKey="Morrow D" first="David A" last="Morrow">David A. Morrow</name><name sortKey="Sabatine, Marc S" sort="Sabatine, Marc S" uniqKey="Sabatine M" first="Marc S" last="Sabatine">Marc S. Sabatine</name><name sortKey="Shannon, Jennifer B" sort="Shannon, Jennifer B" uniqKey="Shannon J" first="Jennifer B" last="Shannon">Jennifer B. Shannon</name><name sortKey="Wiviott, Stephen D" sort="Wiviott, Stephen D" uniqKey="Wiviott S" first="Stephen D" last="Wiviott">Stephen D. Wiviott</name></country><country name="Australie"><noRegion><name sortKey="Aylward, Philip E" sort="Aylward, Philip E" uniqKey="Aylward P" first="Philip E" last="Aylward">Philip E. Aylward</name></noRegion></country><country name="Pologne"><noRegion><name sortKey="Budaj, Andrzej" sort="Budaj, Andrzej" uniqKey="Budaj A" first="Andrzej" last="Budaj">Andrzej Budaj</name></noRegion></country><country name="Suède"><noRegion><name sortKey="Dellborg, Mikael" sort="Dellborg, Mikael" uniqKey="Dellborg M" first="Mikael" last="Dellborg">Mikael Dellborg</name></noRegion></country><country name="Royaume-Uni"><region name="Écosse"><name sortKey="Fox, Keith A A" sort="Fox, Keith A A" uniqKey="Fox K" first="Keith A A" last="Fox">Keith A A. Fox</name></region></country><country name="Allemagne"><noRegion><name sortKey="Hamm, Christian" sort="Hamm, Christian" uniqKey="Hamm C" first="Christian" last="Hamm">Christian Hamm</name></noRegion></country><country name="Hongrie"><region name="Hongrie centrale"><name sortKey="Kiss, Robert G" sort="Kiss, Robert G" uniqKey="Kiss R" first="Robert G" last="Kiss">Robert G. Kiss</name></region></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Lopez Sendon, Jose L" sort="Lopez Sendon, Jose L" uniqKey="Lopez Sendon J" first="Jose L" last="Lopez-Sendon">Jose L. Lopez-Sendon</name></region></country><country name="Pays-Bas"><region name="Gueldre"><name sortKey="Ophuis, Ton Oude" sort="Ophuis, Ton Oude" uniqKey="Ophuis T" first="Ton Oude" last="Ophuis">Ton Oude Ophuis</name></region></country><country name="Ukraine"><noRegion><name sortKey="Parkhomenko, Alexandr" sort="Parkhomenko, Alexandr" uniqKey="Parkhomenko A" first="Alexandr" last="Parkhomenko">Alexandr Parkhomenko</name></noRegion></country><country name="République tchèque"><region name="Moravie"><name sortKey="Spinar, Jindrich" sort="Spinar, Jindrich" uniqKey="Spinar J" first="Jindrich" last="Spinar">Jindrich Spinar</name></region></country><country name="Canada"><noRegion><name sortKey="Tanguay, Jean Francois" sort="Tanguay, Jean Francois" uniqKey="Tanguay J" first="Jean-Francois" last="Tanguay">Jean-Francois Tanguay</name></noRegion><name sortKey="Theroux, Pierre" sort="Theroux, Pierre" uniqKey="Theroux P" first="Pierre" last="Theroux">Pierre Theroux</name></country><country name="Russie"><region name="District fédéral central"><name sortKey="Ruda, Mikhail" sort="Ruda, Mikhail" uniqKey="Ruda M" first="Mikhail" last="Ruda">Mikhail Ruda</name></region></country><country name="France"><region name="Île-de-France"><name sortKey="Steg, P Gabriel" sort="Steg, P Gabriel" uniqKey="Steg P" first="P Gabriel" last="Steg">P Gabriel Steg</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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